Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 4/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.45 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.44 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.44 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.44 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | YAP1 | P46937 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30706131 | 0.88 | PRMT5 (0.56) | PRMT5GPR119YAP1BRD4 | |
| SCHEMBL30706137 | 0.88 | PRMT5 (0.49) | PRMT5CCNT1CCNA2CDK2CDK9 | |
| SCHEMBL24206930 | 0.87 | PRMT5 (0.52) | PRMT5GPR119YAP1STS | |
| SCHEMBL25190804 | 0.86 | PRMT5 (0.41) | PRMT5ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL25190805 | 0.86 | PRMT5 (0.41) | PRMT5ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL29223506 | 0.85 | PRMT5 (0.53) | PRMT5CACNA1BGPR119YAP1 | |
| SCHEMBL23301621 | 0.85 | GPR119 (0.54) | ALDH1A1MAPTGPR119ACHE | |
| SCHEMBL31382255 | 0.85 | PRMT5 (0.53) | PRMT5GPR119YAP1STS | |
| SCHEMBL25168313 | 0.84 | DDB1 (0.51) | PRMT5ALDH1A1MAPTMAPK1L3MBTL1 | |
| SCHEMBL25074065 | 0.84 | GPR119 (0.51) | PRMT5CACNA1BGPR119YAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |