Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 3/20 | 0.50 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ESRRB | O95718 | 1/20 | 0.48 |
| ▸ | ESR1 | P03372 | 1/20 | 0.48 |
| ▸ | ESRRA | P11474 | 1/20 | 0.48 |
| ▸ | ESRRG | P62508 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | SCD5 | Q86SK9 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21963775 | 0.94 | CYP11B2 (0.52) | CYP11B2RORCGPR119ALDH1A1LMNA | |
| SCHEMBL23539079 | 0.94 | GPR119 (0.49) | CYP11B2RORCGPR119ALDH1A1LMNA | |
| SCHEMBL26101978 | 0.92 | MAPK1 (0.54) | CYP11B2RORCGPR119ALDH1A1LMNA | |
| SCHEMBL22805048 | 0.89 | CYP3A4 (0.55) | CYP11B2RORCGPR119ALDH1A1LMNA | |
| SCHEMBL485607 | 0.88 | HDAC2 (0.58) | CYP11B2RORCGPR119ALDH1A1LMNA | |
| SCHEMBL484886 | 0.88 | CYP11B2 (0.55) | CYP11B2GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL485392 | 0.86 | CYP11B2 (0.54) | CYP11B2GPR119ALDH1A1LMNAMAPT | |
| SCHEMBL22804442 | 0.85 | CYP3A4 (0.50) | CYP11B2RORCGPR119ALDH1A1LMNA | |
| SCHEMBL485220 | 0.85 | CYP11B2 (0.53) | CYP11B2RORCGPR119ALDH1A1LMNA | |
| SCHEMBL484102 | 0.85 | HIF1A (0.63) | CYP11B2ALDH1A1CYP3A4CYP2C19MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543871-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | Relay Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2024006781-A1 | ESTROGEN RECEPTOR ALPHA DEGRADERS AND USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2024-01-04 | — | — | WO | disclosed |