Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | GPR3 | P46089 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 6/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL30769631 | 0.96 | HTR2A (0.36) | HTR2AHTR6CYP2D6GPR3SIGMAR1 | |
| Hydrochloric Acid SCHEMBL30769736 | 0.96 | HTR2A (0.36) | HTR2AHTR6CYP2D6GPR3SIGMAR1 | |
| SCHEMBL29386036 | 0.96 | HTR2A (0.39) | HTR2AHTR6CYP2D6GPR3SIGMAR1 | |
| SCHEMBL19630560 | 0.96 | HTR2A (0.39) | HTR2AHTR6CYP2D6GPR3SIGMAR1 | |
| SCHEMBL30388070 | 0.84 | BRD4 (0.35) | HTR2AHTR6CYP2D6SIGMAR1ADRA2B | |
| Hydrochloric Acid SCHEMBL27540339 | 0.82 | ALDH1A1 (0.34) | HTR2AHTR6SIGMAR1ADRA2BADRA2C | |
| Hydrochloric Acid SCHEMBL27437616 | 0.82 | ALDH1A1 (0.34) | HTR2AHTR6CYP2D6SIGMAR1ADRA2B | |
| Hydrochloric Acid SCHEMBL27435805 | 0.82 | ALDH1A1 (0.34) | HTR2AHTR6CYP2D6SIGMAR1ADRA2B | |
| SCHEMBL27591072 | 0.81 | BRD4 (0.37) | CYP2D6SIGMAR1ADRA1ABRD4 | |
| Hydrochloric Acid SCHEMBL3355089 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113195559-B | High temperature resistant pipeline comprising ethylene-based polymer | SABIC环球技术有限责任公司 | 2024-01-19 | — | — | CN | disclosed |