Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IL1B | P01584 | 8/20 | 0.41 |
| ▸ | TNF | P01375 | 2/20 | 0.39 |
| ▸ | NLRP3 | Q96P20 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | PRKCH | P24723 | 2/20 | 0.34 |
| ▸ | PRKCE | Q02156 | 2/20 | 0.34 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.34 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.34 |
| ▸ | PRKCB | P05771 | 1/20 | 0.34 |
| ▸ | LATS1 | O95835 | 3/20 | 0.33 |
| ▸ | IDH2 | P48735 | 1/20 | 0.32 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.32 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30181277 | 0.94 | IL1B (0.46) | IL1BTNFNLRP3KDRKCNH2 | |
| SCHEMBL27157420 | 0.94 | IL1B (0.46) | IL1BTNFNLRP3KDRKCNH2 | |
| SCHEMBL27157422 | 0.86 | KDR (0.39) | IL1BTNFNLRP3KDRPRKCH | |
| SCHEMBL30770615 | 0.86 | KDR (0.39) | IL1BTNFNLRP3KDRPRKCH | |
| SCHEMBL24379633 | 0.85 | NLRP3 (0.40) | IL1BNLRP3KDRPRKCHPRKCE | |
| SCHEMBL27157384 | 0.85 | IL1B (0.34) | IL1BTNFNLRP3KDRPRKCH | |
| SCHEMBL30180834 | 0.85 | IL1B (0.41) | IL1BTNFKDRPRKCHPRKCE | |
| SCHEMBL24855503 | 0.85 | IL1B (0.41) | IL1BTNFKDRPRKCHPRKCE | |
| SCHEMBL30770726 | 0.83 | KDR (0.40) | IL1BTNFNLRP3KDRPRKCH | |
| SCHEMBL27157401 | 0.83 | KDR (0.40) | IL1BTNFNLRP3KDRPRKCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4331668-A2 | COMPOUNDS FOR INHIBITING NLRP3 AND USES THEREOF | Ventus Therapeutics U.S., Inc. (US) | 2024-03-06 | — | — | EP | disclosed |