Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 14/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.72 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.67 |
| ▸ | NPC1 | O15118 | 3/20 | 0.67 |
| ▸ | RAB9A | P51151 | 3/20 | 0.67 |
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.67 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | POLB | P06746 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16592632 | 0.85 | GRM4 (0.75) | GRM4KDM4EHDAC6SMN1; SMN2NPC1 | |
| SCHEMBL15929735 | 0.83 | GRM4 (1.00) | GRM4KDM4EHDAC6SMN1; SMN2NPC1 | |
| SCHEMBL23705777 | 0.83 | GRM4 (1.00) | GRM4KDM4EHDAC6SMN1; SMN2NPC1 | |
| SCHEMBL29412182 | 0.83 | GRM4 (1.00) | GRM4KDM4EHDAC6SMN1; SMN2NPC1 | |
| SCHEMBL16603071 | 0.82 | SMN1; SMN2 (0.70) | GRM4KDM4EHDAC6SMN1; SMN2NPC1 | |
| SCHEMBL5023609 | 0.81 | PTGS2 (0.72) | GRM4ALDH1A1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL16592580 | 0.81 | GRM4 (0.67) | GRM4ALDH1A1KMT2AKDM4EHDAC6 | |
| SCHEMBL16592631 | 0.81 | GRM4 (0.67) | GRM4ALDH1A1KMT2AKDM4EHDAC6 | |
| SCHEMBL16592579 | 0.81 | GRM4 (0.67) | GRM4ALDH1A1KMT2AKDM4EHDAC6 | |
| SCHEMBL17142634 | 0.80 | GRM4 (0.66) | GRM4ALDH1A1KMT2AKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240100018-A1 | COMPOUNDS FOR THE TREATMENT OF A DISEASE OR DISORDER, METHODS FOR IDENTIFYING SAID COMPOUNDS | CEDARS-SINAI MEDICAL CENTER | 2024-03-28 | — | — | US | disclosed |