Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 4/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19207122 | 1.00 | KDM4E (0.54) | KDM4EKMT2AALDH1A1GAAHCRTR1 | |
| SCHEMBL27312661 | 0.83 | KDM4E (0.50) | KDM4EKMT2AALDH1A1GAAADORA2A | |
| SCHEMBL30775086 | 0.82 | LMNA (0.58) | KDM4EKMT2AALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL20773742 | 0.82 | LMNA (0.58) | KDM4EKMT2AALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL28453625 | 0.82 | KDM4E (0.49) | KDM4EKMT2AALDH1A1GAAADORA2A | |
| SCHEMBL17151469 | 0.81 | HCRTR1 (0.40) | KDM4EKMT2AALDH1A1HCRTR1HCRTR2 | |
| SCHEMBL19207160 | 0.81 | CCR1 (0.46) | KDM4EKMT2AHCRTR1PIN1KDM4A | |
| SCHEMBL19207099 | 0.80 | CCR1 (0.46) | KDM4EKMT2AHCRTR1HCRTR2PIN1 | |
| SCHEMBL30775046 | 0.80 | CCR1 (0.46) | KDM4EKMT2AHCRTR1HCRTR2PIN1 | |
| SCHEMBL80459 | 0.79 | ALOX5 (0.61) | KDM4EKMT2AALDH1A1HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688154-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | BIAL - Portela & Ca., S.A. (PT) | 2026-02-11 | — | — | EP | disclosed |
| WO-2025023851-A1 | MORPHOLINE OREXIN RECEPTOR ANTAGONISTS | BIAL - PORTELA & CA., S.A. (PT) | 2025-01-30 | — | — | WO | disclosed |
| CN-111315734-B | Substituted 2-azabicyclo [3.1.1] heptane and 2-azabicyclo [3.2.1] octane derivatives as orexin receptor antagonists | 克罗诺斯治疗有限公司 | 2024-03-08 | — | — | CN | disclosed |