Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 9/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 5/20 | 0.36 |
| ▸ | CASP1 | P29466 | 8/20 | 0.35 |
| ▸ | CASP7 | P55210 | 8/20 | 0.35 |
| ▸ | MEN1 | O00255 | 5/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | USP2 | O75604 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 4/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21729931 | 0.77 | ALDH1A1 (0.46) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL18861713 | 0.75 | KDM4E (0.33) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL3129653 | 0.74 | HSD17B10 (0.50) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL3129639 | 0.72 | HSD17B10 (0.48) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL4926690 | 0.72 | HSD17B10 (0.54) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL29294865 | 0.72 | HSD17B10 (0.48) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL5132886 | 0.72 | ALDH1A1 (0.48) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL15360282 | 0.72 | ALDH1A1 (0.43) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| SCHEMBL14234049 | 0.70 | ALDH1A1 (0.46) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 | |
| Hydrochloric Acid SCHEMBL30189824 | 0.70 | ALDH1A1 (0.46) | ALDH1A1HSD17B10ALOX15KDM4EKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | claimed |
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | DONG-A ST CO., LTD. (KR) | 2025-03-04 | — | — | US | disclosed |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | DONG-A ST CO., LTD. (KR) | 2024-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12240836-B2 | Compounds as GCN2 inhibitors, pharmaceutical compositions and uses thereof | EIF2AK4, GCN1, GCGR | ALDH1A1 3927/4885HSD17B10 289/4885ALOX15 627/4885 |
| US-20240025884-A1 | COMPOUNDS AS GCN2 INHIBITORS, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF | EIF2AK4, GCN1, GCGR | ALDH1A1 3927/4885HSD17B10 289/4885ALOX15 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.