Sugi Predict

Sugi Predict / Compounds / SCHEMBL307772

SCHEMBL307772

SCHEMBL307772

COc1ccccc1NC(=O)CC(=O)Nc1ccc(Oc2ccnc3cc(C#CCN4CCOCC4)sc23)c(F)c1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MET P08581 19/20 0.60
▸ KDR P35968 18/20 0.60
▸ FLT3 P36888 2/20 0.46
▸ PLK4 O00444 1/20 0.46
▸ STK25 O00506 1/20 0.46
▸ CIT O14578 1/20 0.46
▸ AURKA O14965 1/20 0.46
▸ CHUK O15111 1/20 0.46
▸ MUSK O15146 1/20 0.46
▸ EPHB6 O15197 1/20 0.46
▸ MAPK13 O15264 1/20 0.46
▸ MAP3K13 O43283 1/20 0.46
▸ DAPK3 O43293 1/20 0.46
▸ MAP3K7 O43318 1/20 0.46
▸ RIPK2 O43353 1/20 0.46
▸ JAK2 O60674 1/20 0.46
▸ ROCK2 O75116 1/20 0.46
▸ PAK3 O75914 1/20 0.46
▸ CDKL5 O76039 1/20 0.46
▸ STK10 O94804 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL306650 0.93 MET (0.57) METKDRMST1R
SCHEMBL10289233 0.88 MET (0.64) METKDRFLT3PLK4STK25
SCHEMBL2534849 0.86 MET (0.55) METKDRFLT3RETMST1R
SCHEMBL307771 0.86 MET (0.44) METKDRFLT3PLK4STK25
SCHEMBL896688 0.85 MET (0.65) METKDR
SCHEMBL2537356 0.84 RET (0.52) METKDRFLT3RETPDGFRA
SCHEMBL306602 0.83 MET (0.67) METKDR
SCHEMBL895974 0.82 KDR (0.65) METKDRFLT3LCKYES1
SCHEMBL2284026 0.82 MET (0.73) METKDRAURKAFPR1GPR183
SCHEMBL896686 0.82 MET (0.64) METKDRFLT3MST1R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20070004675-A1 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE, INC. 2007-01-04 — — US claimed
US-8329726-B2 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-12-11 — — US disclosed
US-8329726-B2 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-12-11 — — US disclosed
US-20120083482-A1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC. 2012-04-05 — — US disclosed
US-20120083482-A1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING METHYLGENE INC. 2012-04-05 — — US disclosed
US-8093264-B2 Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-01-10 — — US disclosed
US-8093264-B2 Fused heterocycles as inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE INC. (CA) 2012-01-10 — — US disclosed
US-20070004675-A1 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE, INC. 2007-01-04 — — US disclosed
US-20070004675-A1 Inhibitors of VEGF receptor and HGF receptor signaling METHYLGENE, INC. 2007-01-04 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070004675-A1 Inhibitors of VEGF receptor and HGF receptor signaling HGF, MET, FLT1 MET 2/4885KDR 4/4885FLT3 31/4885
US-20120083482-A1 INHIBITORS OF VEGF RECEPTOR AND HGF RECEPTOR SIGNALING HGF, MET, KDR MET 2/4885KDR 3/4885FLT3 106/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.