Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.35 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.32 |
| ▸ | LDHB | P07195 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | VDR | P11473 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30781036 | 0.79 | DGAT1 (0.32) | — | |
| SCHEMBL21392852 | 0.75 | KDM4E (0.52) | KDM4EKMT2ACYP2D6MAPTADAM17 | |
| SCHEMBL3401057 | 0.67 | KDM4E (0.67) | KDM4EKMT2ACYP2D6MAPTL3MBTL1 | |
| SCHEMBL12790220 | 0.66 | KDM4E (0.44) | KDM4EKMT2APOLBL3MBTL1 | |
| Hydrochloric Acid SCHEMBL29054527 | 0.66 | KDM4E (0.65) | KDM4EKMT2ACYP2D6MAPTL3MBTL1 | |
| SCHEMBL12847001 | 0.64 | SLC6A9 (0.44) | KDM4EKMT2A | |
| SCHEMBL950298 | 0.63 | KDM4E (0.65) | KDM4EKMT2ACYP2D6MAPTL3MBTL1 | |
| SCHEMBL30824582 | 0.63 | KDM4E (0.65) | KDM4EKMT2ACYP2D6MAPTL3MBTL1 | |
| SCHEMBL16370745 | 0.62 | KDM4E (0.44) | KDM4EKMT2ACYP2D6MAPTADAM17 | |
| SCHEMBL28072046 | 0.62 | KDM4E (0.59) | KDM4EKMT2ACYP2D6MAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024030651-A1 | GPX4 INHIBITORS AND USE THEREOF | SONATA THERAPEUTICS, INC. (US) | 2024-02-08 | — | — | WO | disclosed |