Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 3/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | CLK1 | P49759 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | OXTR | P30559 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL509566 | 0.77 | EGFR (0.64) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL16655562 | 0.76 | POLB (0.50) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL29363298 | 0.76 | POLB (0.50) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL31473778 | 0.76 | WNT3A (0.62) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL24538470 | 0.75 | EGFR (0.51) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL18300724 | 0.75 | HTT (0.54) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL28283742 | 0.74 | NPC1 (0.64) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL25804253 | 0.74 | THRB (0.52) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL18300154 | 0.74 | HTT (0.52) | EGFRPOLBNR2F2MEN1KMT2A | |
| SCHEMBL31619953 | 0.73 | PDE5A (0.56) | EGFRPOLBNR2F2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117396473-A | Imidazopyridinyl inhibitors of plasma kallikrein | 武田药品工业株式会社 | 2024-01-12 | — | — | CN | disclosed |