Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.52 |
| ▸ | RAB9A | P51151 | 7/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.52 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.52 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.51 |
| ▸ | HPGD | P15428 | 6/20 | 0.51 |
| ▸ | TP53 | P04637 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 3/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27188337 | 0.86 | PPARG (0.63) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29479738 | 0.85 | ALDH1A1 (0.64) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30782727 | 0.81 | MAPT (0.63) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30782726 | 0.81 | MAPT (0.63) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30782729 | 0.80 | PPARG (0.67) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30782717 | 0.79 | PPARG (0.58) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30782724 | 0.79 | MAPT (0.66) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30782723 | 0.79 | MAPT (0.66) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23033325 | 0.78 | ALDH1A1 (0.51) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23033327 | 0.78 | MAPT (0.53) | PPARGALDH1A1NPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109850-A1 | Covalent PPARG inverse-agonists | BAYER AKTIENGESELLSCHAFT (DE) | 2024-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109850-A1 | Covalent PPARG inverse-agonists | PPARG, PPARD, PPARA | PPARG 1/4885ALDH1A1 1224/4885NPC1 1079/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.