Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.56 |
| ▸ | PTGES | O14684 | 1/20 | 0.51 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.47 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | AGPAT2 | O15120 | 3/20 | 0.45 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30782719 | 0.92 | PPARG (0.56) | PPARGPTGESCYP17A1ACSS2MAPK14 | |
| SCHEMBL27188313 | 0.87 | PPARG (0.63) | PPARGPTGESKDM4EMAPTRAB9A | |
| SCHEMBL21017931 | 0.82 | KDM4E (0.44) | PPARGPTGESKDM4EAGPAT2MAPT | |
| SCHEMBL12393054 | 0.80 | BRD4 (0.57) | CYP17A1ACSS2KDM4EMAPTRAB9A | |
| SCHEMBL21018167 | 0.79 | KDM4E (0.41) | PPARGPTGESACSS2KDM4EAGPAT2 | |
| SCHEMBL27188360 | 0.78 | PPARG (0.63) | PPARGPTGESRAB9ANPC1HDAC1 | |
| SCHEMBL30782729 | 0.76 | PPARG (0.67) | PPARGKDM4EMAPTRAB9APOLB | |
| SCHEMBL16329523 | 0.76 | CHEK2 (0.50) | CYP17A1ACSS2BRD4HDAC1HDAC8 | |
| SCHEMBL10361607 | 0.75 | CYP17A1 (0.61) | PPARGCYP17A1MAPK14RAB9ALMNA | |
| SCHEMBL21017912 | 0.73 | ACSS2 (0.43) | PPARGPTGESACSS2KDM4EAGPAT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240109850-A1 | Covalent PPARG inverse-agonists | BAYER AKTIENGESELLSCHAFT (DE) | 2024-04-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240109850-A1 | Covalent PPARG inverse-agonists | PPARG, PPARD, PPARA | PPARG 1/4885PTGES 182/4885CYP17A1 414/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.