SCHEMBL30786983

SCHEMBL30786983

N=C(N)NCCC[C@H](NC(=O)[C@H](N)Cc1ccccc1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](CS)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
▸ KISS1R Q969F8 10/20 0.53
▸ MC4R P32245 2/20 0.53
▸ ACE P12821 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31184496 1.00 KISS1R (0.53) KISS1RMC4RACE
SCHEMBL29476104 1.00 KISS1R (0.53) KISS1RMC4RACE
SCHEMBL29476415 1.00 KISS1R (0.53) KISS1RMC4RACE
SCHEMBL29511055 1.00 KISS1R (0.53) KISS1RMC4RACE
SCHEMBL30276243 0.97 MC4R (0.53) KISS1RMC4RACE
SCHEMBL29511018 0.96 KISS1R (0.58) KISS1RACE
SCHEMBL29511037 0.96 KISS1R (0.58) KISS1RACE
SCHEMBL30166970 0.95 MC4R (0.56) KISS1RMC4R
SCHEMBL31249518 0.95 MC4R (0.55) KISS1RMC4R
SCHEMBL31249537 0.95 MC4R (0.55) KISS1RMC4R

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4554607-A2 METHODS FOR TREATING OBESITY WITH AN MC4R AGONIST Rhythm Pharmaceuticals, Inc. (US) 2025-05-21 — — EP claimed
WO-2024015880-A2 METHODS FOR TREATING OBESITY WITH AN MC4R AGONIST RHYTHM PHARMACEUTICALS, INC. (US) 2024-01-18 — — WO claimed
EP-4711004-A2 METHOD OF TREATING MELANOCORTIN-4 RECEPTOR PATHWAY-ASSOCIATED DISORDERS Rhythm Pharmaceuticals, Inc. (US) 2026-03-18 — — EP disclosed
EP-4554607-A2 METHODS FOR TREATING OBESITY WITH AN MC4R AGONIST Rhythm Pharmaceuticals, Inc. (US) 2025-05-21 — — EP disclosed
WO-2024015880-A2 METHODS FOR TREATING OBESITY WITH AN MC4R AGONIST RHYTHM PHARMACEUTICALS, INC. (US) 2024-01-18 — — WO disclosed
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