Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 8/20 | 0.48 |
| ▸ | PTK2 | Q05397 | 7/20 | 0.47 |
| ▸ | JAK2 | O60674 | 7/20 | 0.44 |
| ▸ | JAK3 | P52333 | 7/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | DAPK3 | O43293 | 3/20 | 0.44 |
| ▸ | PAK4 | O96013 | 3/20 | 0.44 |
| ▸ | RET | P07949 | 3/20 | 0.44 |
| ▸ | LTK | P29376 | 3/20 | 0.44 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | MAP2K2 | P36507 | 3/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 3/20 | 0.44 |
| ▸ | CLK2 | P49760 | 3/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.44 |
| ▸ | MST1R | Q04912 | 3/20 | 0.44 |
| ▸ | MAP4K2 | Q12851 | 3/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27387027 | 0.81 | JAK1 (0.47) | JAK1PTK2JAK2JAK3LRRK2 | |
| SCHEMBL30788214 | 0.81 | JAK1 (0.47) | JAK1PTK2JAK2JAK3LRRK2 | |
| SCHEMBL30788192 | 0.77 | JAK2 (0.70) | JAK1JAK2JAK3MAPK8MAPK9 | |
| SCHEMBL30788200 | 0.76 | JAK1 (0.46) | JAK1PTK2JAK2JAK3AURKA | |
| SCHEMBL27387022 | 0.75 | JAK2 (0.57) | JAK1PTK2JAK2JAK3AURKA | |
| SCHEMBL30788193 | 0.75 | JAK2 (0.57) | JAK1PTK2JAK2JAK3AURKA | |
| SCHEMBL14547717 | 0.73 | LRRK2 (0.62) | PTK2JAK2JAK3AURKADAPK3 | |
| SCHEMBL30788206 | 0.72 | JAK2 (0.45) | JAK1JAK2JAK3LRRK2 | |
| SCHEMBL27388538 | 0.72 | JAK2 (0.45) | JAK1JAK2JAK3LRRK2 | |
| SCHEMBL27387789 | 0.70 | BTK (0.65) | JAK1JAK2JAK3RPS6KA3ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024035771-A2 | ULK3 INHIBITORS AND USES THEREOF | H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) | 2024-02-15 | — | — | WO | disclosed |