Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CRHBP | P24387 | 1/20 | 0.36 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.36 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | RECQL | P46063 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CFTR | P13569 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3075582 | 1.00 | ELANE (0.52) | ELANEKMT2AMEN1POLBCRHBP | |
| SCHEMBL5516075 | 1.00 | ELANE (0.52) | ELANEKMT2AMEN1POLBCRHBP | |
| SCHEMBL3079101 | 1.00 | ELANE (0.52) | ELANEKMT2AMEN1POLBCRHBP | |
| SCHEMBL3076587 | 0.84 | ELANE (0.51) | ELANEKMT2AMEN1RIPK1 | |
| SCHEMBL3076591 | 0.84 | ELANE (0.51) | ELANEKMT2AMEN1RIPK1 | |
| SCHEMBL6409371 | 0.84 | ELANE (0.51) | ELANEKMT2AMEN1RIPK1 | |
| SCHEMBL6860240 | 0.80 | ELANE (0.47) | ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL6860243 | 0.80 | ELANE (0.47) | ELANESMN1; SMN2ALDH1A1 | |
| SCHEMBL9407836 | 0.79 | ELANE (0.57) | ELANEKMT2AMEN1POLBSIRT3 | |
| SCHEMBL9407840 | 0.79 | ELANE (0.57) | ELANEKMT2AMEN1POLBSIRT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0617018-B1 | Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes | BRISTOL MYERS SQUIBB CO (US) | 2003-10-01 | — | — | EP | claimed |
| US-20020137927-A1 | Novel beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes | THOTTATHIL JOHN K (US) | 2002-09-26 | — | — | US | claimed |
| US-6350887-B1 | CHEMICAL INTERMEDIATES FOR ANTICARCINOGENIC AGENTS | BRISTOL-MYERS SQUIBB COMPANY | 2002-02-26 | — | — | US | claimed |
| US-6310201-B1 | (3R-CIS)-1-BENZOYL-3-(1-METHOXY-1-METHYLETHOXY)-4-PHENYL-2-AZE TIDINONE. | BRISTOL-MYERS SQUIBB COMPANY | 2001-10-30 | — | — | US | claimed |
| EP-0617018-A1 | Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-09-28 | — | — | EP | claimed |
| US-20100228038-A1 | PROCESSES FOR THE PRODUCTION OF POLYCYCLIC FUSED RING COMPOUNDS | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100228038-A1 | PROCESSES FOR THE PRODUCTION OF POLYCYCLIC FUSED RING COMPOUNDS | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-20100228038-A1 | PROCESSES FOR THE PRODUCTION OF POLYCYCLIC FUSED RING COMPOUNDS | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-09-09 | — | — | US | disclosed |
| US-7667055-B2 | Processes for the production of polycyclic fused ring compounds | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-7667055-B2 | Processes for the production of polycyclic fused ring compounds | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| US-7667055-B2 | Processes for the production of polycyclic fused ring compounds | FLORIDA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2010-02-23 | — | — | US | disclosed |
| EP-1919926-A2 | PROCESSES FOR THE PRODUCTION OF POLYCYCLIC FUSED RING COMPOUNDS | Florida State University Research Foundation, Inc. (US) | 2008-05-14 | — | — | EP | disclosed |
| EP-0617018-A1 | Beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes | BRISTOL-MYERS SQUIBB COMPANY (US) | 1994-09-28 | — | — | EP | disclosed |
| EP-0605637-A4 | PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND -G(B)-LACTAMS. | UNIV FLORIDA STATE (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0605638-A4 | METAL ALKOXIDES. | UNIV FLORIDA STATE (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0605637-A1 | PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND $g(b)-LACTAMS | FLORIDA STATE UNIVERSITY (US) | 1994-07-13 | — | — | EP | disclosed |
| EP-0605638-A1 | METAL ALKOXIDES | FLORIDA STATE UNIVERSITY (US) | 1994-07-13 | — | — | EP | disclosed |
| US-5274124-A | Metal alkoxides | FLORIDA STATE UNIVERSITY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1993006094-A1 | METAL ALKOXIDES | FLORIDA STATE UNIVERSITY (US) | 1993-04-01 | — | — | WO | disclosed |
| WO-1993006079-A1 | PREPARATION OF SUBSTITUTED ISOSERINE ESTERS USING METAL ALKOXIDES AND β-LACTAMS | FLORIDA STATE UNIVERSITY (US) | 1993-04-01 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020137927-A1 | Novel beta-lactams, methods for the preparation of taxanes, and sidechain-bearing taxanes | TOP2A, TOP2B, TUBB1 | ELANE 1723/4885KMT2A 4008/4885MEN1 880/4885 |
| US-20100228038-A1 | PROCESSES FOR THE PRODUCTION OF POLYCYCLIC FUSED RING COMPOUNDS | COASY, PARG, PIN4 | ELANE 4817/4885KMT2A 1366/4885MEN1 179/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.