Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.61 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.61 |
| ▸ | PARP10 | Q53GL7 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | PARP4 | Q9UKK3 | 2/20 | 0.45 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.45 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.45 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.45 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | PARP1 | P09874 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL56532 | 0.86 | PARP10 (0.74) | TSHRCYP3A4PARP10LMNAL3MBTL1 | |
| SCHEMBL7642130 | 0.86 | PARP10 (0.74) | TSHRCYP3A4PARP10LMNAL3MBTL1 | |
| Terephthalamide SCHEMBL437011 | 0.86 | PARP10 (0.74) | TSHRCYP3A4PARP10LMNAL3MBTL1 | |
| SCHEMBL6381344 | 0.84 | CYP3A4 (0.64) | TSHRCYP3A4MAPK1PARP10HPGD | |
| Hydrochloric Acid SCHEMBL4408462 | 0.84 | PARP10 (0.71) | TSHRCYP3A4PARP10LMNAL3MBTL1 | |
| Water SCHEMBL6343332 | 0.84 | PARP10 (0.71) | TSHRCYP3A4PARP10LMNAL3MBTL1 | |
| SCHEMBL2978952 | 0.83 | HPGD (0.64) | TSHRCYP3A4PARP10HPGDLMNA | |
| SCHEMBL900829 | 0.83 | TSHR (0.61) | TSHRCYP3A4MAPK1HPGDLMNA | |
| Benzene SCHEMBL28558933 | 0.81 | PARP10 (0.68) | TSHRCYP3A4PARP10L3MBTL1KMT2A | |
| Benzene SCHEMBL6865184 | 0.81 | PARP10 (0.68) | TSHRCYP3A4PARP10L3MBTL1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | THE BURNHAM INSTITUTE | 2010-10-14 | — | — | US | disclosed |
| US-7741521-B2 | 4-phenylsulfanyl-phenylamine derivatives used as BH3 Interacting Domain Death Antagonist (BID), for the treatment of neurodegenerative diseases, liver inflammation, multiple sclerosis, heart disease, ischemic injury and for controlling apoptotic cascade | THE BURNHAM INSTITUTE (US) | 2010-06-22 | — | — | US | disclosed |
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | THE BURNHAM INSTITUTE (US) | 2007-08-09 | — | — | US | disclosed |
| WO-2006004622-A2 | INHIBITION OF BID-INDUCED CELL-DEATH USING SMALL ORGANIC MOLECULES | THE BURNHAM INSTITUTE (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | BID, BAD, TMBIM6 | TSHR 4415/4885CYP3A4 2495/4885MAPK1 1548/4885 |
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | BID, BAD, TMBIM6 | TSHR 4452/4885CYP3A4 2877/4885MAPK1 2029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.