Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 2/20 | 0.42 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.42 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ENPP2 | Q13822 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461346 | 1.00 | SMARCA2 (0.42) | SMARCA2SMARCA4PBRM1POLBENPP2 | |
| SCHEMBL30796853 | 0.87 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1POLBMAP4K4 | |
| SCHEMBL27461169 | 0.87 | SMARCA2 (0.52) | SMARCA2SMARCA4PBRM1POLBMAP4K4 | |
| SCHEMBL27461347 | 0.83 | SMARCA2 (0.47) | SMARCA2SMARCA4PBRM1ENPP2NR1H2 | |
| SCHEMBL30796952 | 0.83 | SMARCA2 (0.47) | SMARCA2SMARCA4PBRM1ENPP2NR1H2 | |
| SCHEMBL18502950 | 0.78 | WNT3A (0.44) | POLBENPP2NR1H2ESR2GPR119 | |
| SCHEMBL27461344 | 0.77 | NR1H2 (0.42) | POLBENPP2NR1H2ESR2GPR119 | |
| SCHEMBL30796230 | 0.76 | GRM1 (0.47) | GRM1CNR1 | |
| SCHEMBL30796546 | 0.76 | NR1H2 (0.41) | POLBENPP2NR1H2ESR2MAP4K4 | |
| SCHEMBL30796736 | 0.75 | SMARCA2 (0.41) | SMARCA2SMARCA4PBRM1POLBENPP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4539849-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244764-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |