Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 7/20 | 0.61 |
| ▸ | SMARCA4 | P51532 | 7/20 | 0.61 |
| ▸ | PBRM1 | Q86U86 | 7/20 | 0.61 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK3 | P52333 | 3/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.42 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.42 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.41 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 3/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27461726 | 1.00 | SMARCA2 (0.61) | SMARCA2SMARCA4PBRM1NAMPTMAPT | |
| SCHEMBL31548738 | 0.87 | SMARCA2 (0.65) | SMARCA2SMARCA4PBRM1NAMPTJAK2 | |
| SCHEMBL27461434 | 0.85 | SMARCA2 (0.62) | SMARCA2SMARCA4PBRM1NAMPTJAK2 | |
| SCHEMBL30797067 | 0.85 | SMARCA2 (0.62) | SMARCA2SMARCA4PBRM1NAMPTJAK2 | |
| SCHEMBL30606905 | 0.84 | SMARCA2 (0.71) | SMARCA2SMARCA4PBRM1MAPTSMN1; SMN2 | |
| SCHEMBL20009090 | 0.84 | SMARCA2 (0.71) | SMARCA2SMARCA4PBRM1MAPTSMN1; SMN2 | |
| SCHEMBL18038859 | 0.81 | PBRM1 (0.66) | SMARCA2SMARCA4PBRM1NR1I2NR1H2 | |
| SCHEMBL30606896 | 0.81 | PBRM1 (0.66) | SMARCA2SMARCA4PBRM1NR1I2NR1H2 | |
| SCHEMBL24514506 | 0.79 | PBRM1 (0.75) | SMARCA2SMARCA4PBRM1GPR119NR1I2 | |
| SCHEMBL31548745 | 0.79 | PBRM1 (0.57) | SMARCA2SMARCA4PBRM1NAMPTJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4539849-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 Therapeutics, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244764-A1 | COMPOUNDS FOR THE TARGETED DEGRADATION OF SMARCA2 | C4 THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |