Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 9/20 | 0.57 |
| ▸ | SMARCA2 | P51531 | 8/20 | 0.57 |
| ▸ | SMARCA4 | P51532 | 8/20 | 0.57 |
| ▸ | BRD4 | O60885 | 2/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.44 |
| ▸ | SRC | P12931 | 4/20 | 0.42 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | JAK2 | O60674 | 2/20 | 0.41 |
| ▸ | JAK3 | P52333 | 2/20 | 0.41 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | ABL2 | P42684 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.39 |
| ▸ | CDK9 | P50750 | 1/20 | 0.39 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31548738 | 0.91 | SMARCA2 (0.65) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL31548731 | 0.84 | SMARCA2 (0.46) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30520304 | 0.82 | SMARCA2 (0.50) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL25345477 | 0.82 | SMARCA2 (0.50) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL31548779 | 0.82 | SMARCA2 (0.57) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30796907 | 0.79 | SMARCA2 (0.61) | PBRM1SMARCA2SMARCA4NR1I2JAK2 | |
| SCHEMBL27461726 | 0.79 | SMARCA2 (0.61) | PBRM1SMARCA2SMARCA4NR1I2JAK2 | |
| SCHEMBL18038859 | 0.79 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL30606896 | 0.79 | PBRM1 (0.66) | PBRM1SMARCA2SMARCA4BRD4NR1I2 | |
| SCHEMBL22776665 | 0.79 | SMARCA2 (0.58) | PBRM1SMARCA2SMARCA4BRD4NR1I2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025094065-A1 | AMINO-SUBSTITUTED PYRIDAZINE COMPOUNDS AS SMARCA2 AND/OR SMARCA4 DEGRADERS | AURIGENE ONCOLOGY LIMITED (IN) | 2025-05-08 | — | — | WO | disclosed |