Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.32 |
| ▸ | SLC6A7 | Q99884 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15553459 | 0.79 | SMN1; SMN2 (0.46) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL2234874 | 0.73 | GAA (0.44) | ALDH1A1KMT2AMEN1GSK3BNPC1 | |
| SCHEMBL30797258 | 0.72 | CCNA2 (0.40) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL30797099 | 0.69 | NPC1 (0.45) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL30797129 | 0.69 | ELANE (0.44) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL6855304 | 0.68 | HTR2A (0.42) | ALDH1A1KDM4E | |
| SCHEMBL6855299 | 0.68 | HTR2A (0.42) | ALDH1A1KDM4E | |
| SCHEMBL8305787 | 0.68 | GAA (0.46) | CDK4CCNA2CCND1CCNE1CDK2 | |
| SCHEMBL16701852 | 0.67 | DDB1 (0.39) | CDK4CCNA2CCND1CCNE1CDK2 | |
| Hydrochloric Acid SCHEMBL2896840 | 0.67 | KDM4E (0.42) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244817-A1 | SUBSTITUTED PIPERIDINES AS CK1A DEGRADERS | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |