Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 2/20 | 0.40 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.37 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 3/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15553459 | 0.77 | SMN1; SMN2 (0.46) | CCNA2CDK2CDK4CCND1CCNE1 | |
| SCHEMBL18766803 | 0.75 | KDM4E (0.40) | CCNA2CDK2KDM4EGRM1GPR119 | |
| SCHEMBL30797099 | 0.74 | NPC1 (0.45) | CCNA2CDK2CDK4CCND1CCNE1 | |
| SCHEMBL22772522 | 0.72 | KDM4E (0.38) | CCNA2CDK2KDM4EGRM1GPR119 | |
| SCHEMBL30797241 | 0.72 | CDK4 (0.35) | CCNA2CDK2CDK4CCND1CCNE1 | |
| SCHEMBL22772544 | 0.70 | KDM4E (0.35) | CCNA2CDK2KDM4EGRM1P4HTM | |
| SCHEMBL20956364 | 0.70 | CDK4 (0.47) | CCNA2CDK2CDK4CCND1CCNE1 | |
| SCHEMBL14171815 | 0.68 | KDM4E (0.38) | KDM4EGRM1GPR119RXFP1OPRM1 | |
| SCHEMBL30797129 | 0.68 | ELANE (0.44) | CCNA2CDK2CDK4CCND1CCNE1 | |
| SCHEMBL6648422 | 0.68 | LATS1 (0.45) | TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023244817-A1 | SUBSTITUTED PIPERIDINES AS CK1A DEGRADERS | MONTE ROSA THERAPEUTICS, INC. (US) | 2023-12-21 | — | — | WO | disclosed |