Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKZF2 | Q9UKS7 | 5/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 12/20 | 0.39 |
| ▸ | IKZF1 | Q13422 | 4/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.38 |
| ▸ | IKZF3 | Q9UKT9 | 6/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | MAP1LC3B | Q9GZQ8 | 2/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27092882 | 1.00 | IKZF2 (0.42) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL24717420 | 1.00 | IKZF2 (0.42) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL30798631 | 0.87 | IKZF2 (0.47) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL24717737 | 0.87 | IKZF2 (0.47) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL25133969 | 0.82 | CRBN (0.43) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL29928166 | 0.82 | CRBN (0.43) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL29132187 | 0.82 | CRBN (0.43) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL22345825 | 0.81 | IKZF2 (0.61) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL31025903 | 0.81 | IKZF2 (0.61) | IKZF2CRBNIKZF1DDB1IKZF3 | |
| SCHEMBL25134262 | 0.81 | CRBN (0.44) | IKZF2CRBNIKZF1DDB1IKZF3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4323352-A1 | MODULATORS OF BCL6 PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2024-02-21 | — | — | EP | disclosed |