Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 3/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | DBH | P09172 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25852271 | 0.87 | KMT2A (0.49) | SMN1; SMN2MAPK14MAPK1 | |
| SCHEMBL25852152 | 0.86 | DBH (0.41) | EGLN1MAPTTP53KDM4ELMNA | |
| SCHEMBL20936157 | 0.85 | MAPK14 (0.58) | TP53KDM4EALDH1A1SMN1; SMN2MAPK14 | |
| SCHEMBL25852199 | 0.80 | KMT2A (0.47) | MAPTLMNAPOLBALDH1A1DBH | |
| SCHEMBL28003373 | 0.80 | EGLN1 (0.61) | EGLN1MAPTTP53KDM4ELMNA | |
| SCHEMBL20504077 | 0.79 | MAPK14 (0.37) | EGLN1MAPTTP53KDM4ELMNA | |
| SCHEMBL20503881 | 0.79 | MAPK14 (0.40) | EGLN1MAPTKDM4ELMNAPOLB | |
| SCHEMBL25857254 | 0.79 | MAPT (0.42) | MAPTTP53KDM4ELMNAPOLB | |
| SCHEMBL18764601 | 0.79 | ALDH1A1 (0.55) | EGLN1MAPTTP53KDM4ELMNA | |
| SCHEMBL18860569 | 0.78 | EGLN1 (0.53) | EGLN1MAPTTP53KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023135233-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV DISCOVERY (FR) | 2023-07-20 | — | — | WO | disclosed |
| EP-4212531-A1 | AZAINDOLE DERIVATIVES AND THEIR USE AS ERK KINASE INHIBITORS | AGV Discovery (FR) | 2023-07-19 | — | — | EP | disclosed |