Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 9/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 5/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 4/20 | 0.43 |
| ▸ | PDE4A | P27815 | 4/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30798950 | 0.85 | MAPT (0.44) | MAPTSMN1; SMN2GLAADORA2BADORA2A | |
| SCHEMBL797375 | 0.81 | MAPT (0.50) | MAPTSMN1; SMN2GLAADORA2BADORA2A | |
| SCHEMBL27384925 | 0.75 | ADORA2B (0.37) | MAPTGLAADORA2BADORA2AADORA3 | |
| SCHEMBL30799260 | 0.75 | MAPT (0.40) | MAPTSMN1; SMN2GLAADORA2BADORA2A | |
| SCHEMBL8541305 | 0.72 | ADORA2B (0.56) | ADORA2BADORA2AADORA3KDM4EMEN1 | |
| SCHEMBL9049650 | 0.72 | SMN1; SMN2 (0.39) | MAPTSMN1; SMN2GLAADORA2BADORA2A | |
| SCHEMBL5054515 | 0.71 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2GLAADORA2BADORA2A | |
| SCHEMBL1945901 | 0.71 | ATM (0.53) | MAPTSMN1; SMN2GLAADORA2BADORA2A | |
| SCHEMBL1565331 | 0.70 | MAPT (0.69) | MAPTSMN1; SMN2GLAADORA2BADORA2A | |
| SCHEMBL1943501 | 0.70 | MAPT (0.47) | MAPTSMN1; SMN2GLAADORA2BADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |