Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | ADORA2B | P29275 | 8/20 | 0.38 |
| ▸ | PDE4A | P27815 | 7/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 7/20 | 0.38 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.38 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30799166 | 0.72 | MAPT (0.47) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL30799260 | 0.69 | MAPT (0.40) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL8541305 | 0.67 | ADORA2B (0.56) | ADORA2BADORA2AADORA3KDM4EADORA1 | |
| SCHEMBL5054515 | 0.66 | SMN1; SMN2 (0.60) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL9765881 | 0.65 | SMN1; SMN2 (0.46) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL28328175 | 0.64 | ADORA2A (0.47) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL5051980 | 0.62 | SMN1; SMN2 (0.44) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL559878 | 0.62 | MAPT (0.50) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL17935736 | 0.62 | APEX1 (0.54) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C | |
| SCHEMBL16004375 | 0.62 | NPSR1 (0.58) | SMN1; SMN2ADORA2BPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0404525-B1 | Sulfur-containing fused pyrimidine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-05-15 | — | — | EP | disclosed |