Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.45 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.45 |
| ▸ | EIF4H | Q15056 | 1/20 | 0.45 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15108153 | 0.83 | RAB9A (0.73) | NPC1RAB9AKMT2AALDH1A1GAA | |
| SCHEMBL27383390 | 0.83 | KMT2A (0.51) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL30799163 | 0.83 | KMT2A (0.51) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL3332514 | 0.81 | KMT2A (0.68) | KMT2AALDH1A1GAAMEN1SMN1; SMN2 | |
| SCHEMBL12432966 | 0.81 | KDM4E (0.64) | NPC1RAB9AKMT2AALDH1A1GAA | |
| SCHEMBL15765838 | 0.81 | ALDH1A1 (0.71) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL27884370 | 0.81 | CYP1A2 (0.55) | NPC1RAB9AKMT2AALDH1A1GAA | |
| SCHEMBL15718583 | 0.81 | HPGD (0.64) | NPC1RAB9AKMT2AALDH1A1GAA | |
| SCHEMBL3219456 | 0.79 | IDO1 (0.50) | NPC1RAB9AKMT2AALDH1A1MEN1 | |
| SCHEMBL24463666 | 0.79 | KMT2A (0.48) | RAB9AKMT2AALDH1A1GAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024050825-A1 | COMPOUNDS AS MLKL INHIBITORS | NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) | 2024-03-14 | — | — | WO | disclosed |