Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 11/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 10/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 10/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.64 |
| ▸ | NNMT | P40261 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 4/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30801504 | 0.97 | HDAC1 (0.68) | HDAC1HDAC3HDAC2HDAC6NNMT | |
| SCHEMBL30873312 | 0.88 | HDAC1 (0.54) | HDAC1HDAC3HDAC2HDAC6NNMT | |
| SCHEMBL4730145 | 0.78 | HDAC3 (1.00) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL17005755 | 0.77 | HDAC3 (0.49) | HDAC1HDAC3HDAC2HDAC6NNMT | |
| SCHEMBL8683599 | 0.74 | MAPK1 (0.52) | HDAC1HDAC3HDAC2HDAC6NNMT | |
| SCHEMBL23261878 | 0.74 | MAPK8 (0.51) | HDAC1HDAC3HDAC2HDAC6NNMT | |
| SCHEMBL8738722 | 0.74 | HDAC3 (0.63) | HDAC1HDAC3HDAC2HDAC6 | |
| SCHEMBL14937385 | 0.73 | HDAC6 (0.71) | HDAC1HDAC3HDAC2HDAC6VNN1 | |
| SCHEMBL4764392 | 0.71 | NNMT (0.58) | NNMTVNN1 | |
| SCHEMBL29933906 | 0.71 | FFAR2 (0.43) | HDAC1HDAC3HDAC2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4328223-A2 | SUBSTITUTED DIAMINOCARBOXAMIDE AND DIAMINOCARBONITRILE PYRIMIDINES, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, LLC (US) | 2024-02-28 | — | — | EP | disclosed |