Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 5/20 | 0.34 |
| ▸ | EML4 | Q9HC35 | 4/20 | 0.34 |
| ▸ | ALK | Q9UM73 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 5/20 | 0.34 |
| ▸ | LCK | P06239 | 4/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 4/20 | 0.33 |
| ▸ | EPAS1 | Q99814 | 4/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK4 | P11802 | 1/20 | 0.33 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.33 |
| ▸ | CCND3 | P30281 | 1/20 | 0.33 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.33 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
| ▸ | ROS1 | P08922 | 1/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24943817 | 1.00 | IKBKE (0.36) | IKBKETBK1SYKEGFREML4 | |
| SCHEMBL24943822 | 1.00 | IKBKE (0.36) | IKBKETBK1SYKEGFREML4 | |
| SCHEMBL24944452 | 1.00 | IKBKE (0.36) | IKBKETBK1SYKEGFREML4 | |
| Formic Acid SCHEMBL30205487 | 0.97 | IKBKE (0.34) | IKBKETBK1SYKEGFREML4 | |
| Formic Acid SCHEMBL31195388 | 0.97 | IKBKE (0.34) | IKBKETBK1SYKEGFREML4 | |
| Formic Acid SCHEMBL30205753 | 0.97 | IKBKE (0.34) | IKBKETBK1SYKEGFREML4 | |
| Formic Acid SCHEMBL29173328 | 0.97 | IKBKE (0.34) | IKBKETBK1SYKEGFREML4 | |
| SCHEMBL24943840 | 0.90 | IKBKE (0.46) | IKBKETBK1SYKEML4ALK | |
| SCHEMBL30205589 | 0.90 | IKBKE (0.46) | IKBKETBK1SYKEML4ALK | |
| SCHEMBL24944443 | 0.89 | EML4 (0.36) | IKBKETBK1SYKEGFREML4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | claimed |
| CN-117693503-A | Substituted pyrazine-2-carboxamides as HPK1 inhibitors for the treatment of cancer | 阿斯利康(瑞典)有限公司 | 2024-03-12 | — | — | CN | disclosed |