Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EML4 | Q9HC35 | 8/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 8/20 | 0.36 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 4/20 | 0.35 |
| ▸ | RET | P07949 | 4/20 | 0.35 |
| ▸ | ROS1 | P08922 | 4/20 | 0.35 |
| ▸ | FLT3 | P36888 | 4/20 | 0.35 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | LCK | P06239 | 3/20 | 0.34 |
| ▸ | BTK | Q06187 | 2/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24944446 | 1.00 | EML4 (0.36) | EML4ALKSYKJAK3RET | |
| SCHEMBL24944169 | 1.00 | EML4 (0.36) | EML4ALKSYKJAK3RET | |
| Formic Acid SCHEMBL30205519 | 0.97 | EML4 (0.34) | EML4ALKSYKJAK3RET | |
| Formic Acid SCHEMBL30205526 | 0.97 | EML4 (0.34) | EML4ALKSYKJAK3RET | |
| Formic Acid SCHEMBL29173283 | 0.97 | EML4 (0.34) | EML4ALKSYKJAK3RET | |
| SCHEMBL24944172 | 0.90 | TBK1 (0.39) | EML4ALKSYKRETROS1 | |
| SCHEMBL24944452 | 0.89 | IKBKE (0.36) | EML4ALKSYKJAK3RET | |
| SCHEMBL24943822 | 0.89 | IKBKE (0.36) | EML4ALKSYKJAK3RET | |
| SCHEMBL24943817 | 0.89 | IKBKE (0.36) | EML4ALKSYKJAK3RET | |
| SCHEMBL30801807 | 0.89 | IKBKE (0.36) | EML4ALKSYKJAK3RET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023001794-A1 | SUBSTITUTED PYRAZINE-2-CARBOXAMIDES AS HPK1 INHIBITORS FOR THE TREATMENT OF CANCER | ASTRAZENECA AB (SE) | 2023-01-26 | — | — | WO | disclosed |