SCHEMBL30802461

SCHEMBL30802461

CC(C)(C)OC(=O)N1CCN(Cc2ccc(Nc3nc(-c4ccccc4)ccc3[N+](=O)[O-])cc2)CC1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
JAK2 O60674 2/20 0.44
SYK P43405 1/20 0.44
ACKR3 P25106 2/20 0.42
BLM P54132 1/20 0.42
L3MBTL1 Q9Y468 1/20 0.42
MGLL Q99685 2/20 0.42
FAAH O00519 2/20 0.42
JAK3 P52333 1/20 0.42
PTPRB P23467 1/20 0.41
KDM4E B2RXH2 2/20 0.40
GAA P10253 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
HTT P42858 1/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
ALDH1A1 P00352 1/20 0.39
TBK1 Q9UHD2 1/20 0.39
CKS1B P61024 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27225984 1.00 JAK2 (0.44) JAK2SYKACKR3BLML3MBTL1
SCHEMBL27227310 0.89 TNIK (0.40) JAK2SYKKDM4EMAPTCYP2C9
SCHEMBL27227543 0.87 VEGFA (0.42) BLML3MBTL1MGLLFAAHMAPT
SCHEMBL27226835 0.85 SIGMAR1 (0.46) L3MBTL1CKS1BSKP1SKP2
SCHEMBL30802389 0.85 SIGMAR1 (0.46) L3MBTL1CKS1BSKP1SKP2
SCHEMBL31420375 0.84 NAMPT (0.51) JAK2SYKJAK3
SCHEMBL13600191 0.84 MAPT (0.51) MGLLKDM4EGAAMAPTCYP2C9
SCHEMBL31420326 0.82 NAMPT (0.40) JAK2JAK3PTPRB
SCHEMBL27227315 0.82 TBK1 (0.46) JAK2KDM4EGAAMAPTSMN1; SMN2
SCHEMBL25385291 0.81 ABCG2 (0.41) MAPTCYP2C9CYP2C19HTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4594318-A1 AKT1 MODULATORS Alterome Therapeutics, Inc. (US) 2025-08-06 EP disclosed
WO-2024107565-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2024-05-23 WO disclosed
WO-2024073371-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2024-04-04 WO disclosed
WO-2024064026-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2024-03-28 WO disclosed
WO-2024054512-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2024-03-14 WO disclosed