SCHEMBL30804366

SCHEMBL30804366

Nc1cc2c(cc1Cl)C(=O)c1ccccc1C2=O

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.55
RAB9A P51151 3/20 0.55
SMN1; SMN2 Q16637 3/20 0.55
ALDH1A1 P00352 2/20 0.55
TDP1 Q9NUW8 2/20 0.55
MAPK1 P28482 2/20 0.55
TP53 P04637 1/20 0.55
CYP3A4 P08684 1/20 0.55
TSHR P16473 1/20 0.55
ADORA2A P29274 3/20 0.53
MEN1 O00255 4/20 0.50
KMT2A Q03164 4/20 0.50
CDC25B P30305 1/20 0.50
PTPRC P08575 4/20 0.48
S100A4 P26447 3/20 0.48
POLB P06746 3/20 0.48
APAF1 O14727 2/20 0.48
TDP2 O95551 2/20 0.48
LMNA P02545 2/20 0.48
PLA2G1B P04054 2/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8777800 1.00 NPC1 (0.55) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL8663806 0.87 GAA (0.52) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL29651770 0.84 MEN1 (0.63) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL2125571 0.84 MEN1 (0.63) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL6029304 0.84 NPC1 (0.67) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL6230652 0.80 NPC1 (0.61) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL1132044 0.75 ELANE (0.55) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL29587496 0.75 ELANE (0.55) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL27428387 0.75 BCL2 (0.72) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1
SCHEMBL8770711 0.75 ALDH1A1 (0.55) NPC1RAB9ASMN1; SMN2ALDH1A1TDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-117700767-A Preparation method of secondary amine resin, polyurethane and MBBR filler 厦门理工学院 2024-03-15 CN disclosed