Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CNR2 | P34972 | 6/20 | 0.47 |
| ▸ | ERN1 | O75460 | 2/20 | 0.46 |
| ▸ | ADK | P55263 | 1/20 | 0.43 |
| ▸ | ATR | Q13535 | 2/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3081815 | 0.90 | CNR2 (0.47) | CNR2JAK1 | |
| SCHEMBL3080789 | 0.87 | FYN (0.48) | ATR | |
| SCHEMBL3083714 | 0.84 | PRKDC (0.52) | PRKDCGAA | |
| SCHEMBL3084803 | 0.80 | CNR2 (0.50) | PRKDCCNR2ADKATRJAK1 | |
| SCHEMBL3084701 | 0.79 | MCHR1 (0.47) | ATR | |
| SCHEMBL3090574 | 0.76 | KDM4E (0.48) | PRKDCCNR2ATR | |
| SCHEMBL3089794 | 0.74 | USP7 (0.44) | GAAADK | |
| SCHEMBL5384466 | 0.74 | ALDH1A1 (0.41) | GAA | |
| SCHEMBL28570789 | 0.73 | HSP90AA1 (0.47) | GAA | |
| SCHEMBL3239421 | 0.72 | CNR2 (0.66) | CNR2ERN1ATR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227880-A1 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2010-09-09 | — | — | US | disclosed |
| EP-1984375-A2 | CHEMICAL COMPOUNDS | Smithkline Beecham Corporation (US) | 2008-10-29 | — | — | EP | disclosed |
| WO-2007087548-A9 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2007-09-27 | — | — | WO | disclosed |
| WO-2007087548-A2 | CHEMICAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100227880-A1 | CHEMICAL COMPOUNDS | CYP3A5, SLC10A1, ABCB11 | PRKDC 4406/4885GAA 196/4885CNR2 589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.