Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30806608 | 0.79 | CYP1A2 (0.46) | ALDH1A1KMT2AUSP2CYP1A2CYP3A4 | |
| SCHEMBL30806695 | 0.77 | KDM4E (0.51) | ALDH1A1KMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL617824 | 0.73 | TNF (0.68) | TDP1ALDH1A1KMT2ATSHRMEN1 | |
| SCHEMBL28898444 | 0.73 | CFTR (0.67) | ALDH1A1KMT2ACYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30806419 | 0.71 | CFTR (0.60) | KMT2AMEN1GAACFTR | |
| SCHEMBL8039631 | 0.70 | PPARG (0.68) | ALDH1A1HSD17B10PPARG | |
| SCHEMBL14263338 | 0.69 | NPC1 (0.53) | KMT2AMAPTTP53SMN1; SMN2LMNA | |
| SCHEMBL2314971 | 0.69 | MMP13 (0.56) | SMN1; SMN2HTT | |
| SCHEMBL28095814 | 0.69 | KDR (0.68) | KMT2AMEN1SMN1; SMN2KDM4EPPARG | |
| SCHEMBL18391563 | 0.69 | BRD4 (0.84) | BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561561-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | Septerna, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024026076-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | SEPTERNA, INC. (US) | 2024-02-01 | — | — | WO | disclosed |