Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 8/20 | 0.65 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | DHFR | P00374 | 1/20 | 0.49 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30806419 | 0.86 | CFTR (0.60) | CFTRALOX5PTGS2ALOX15MEN1 | |
| SCHEMBL28987743 | 0.81 | MEN1 (0.71) | CFTRALOX5PTGS2ALOX15MEN1 | |
| SCHEMBL31441369 | 0.81 | MEN1 (0.71) | CFTRALOX5PTGS2ALOX15MEN1 | |
| SCHEMBL19032835 | 0.80 | CFTR (0.81) | CFTRALOX5PTGS2ALOX15MEN1 | |
| SCHEMBL19046220 | 0.79 | CFTR (0.80) | CFTRALOX5PTGS2ALOX15MEN1 | |
| SCHEMBL19032802 | 0.79 | CFTR (0.80) | CFTRALOX5PTGS2ALOX15MEN1 | |
| SCHEMBL19032095 | 0.79 | CFTR (1.00) | CFTR | |
| SCHEMBL29478065 | 0.79 | CFTR (1.00) | CFTR | |
| SCHEMBL30807014 | 0.78 | PKM (0.55) | CFTRALOX5PTGS2ALOX15MEN1 | |
| SCHEMBL12165517 | 0.78 | CNR2 (0.47) | CFTRALOX5PTGS2ALOX15MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4561561-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | Septerna, Inc. (US) | 2025-06-04 | — | — | EP | disclosed |
| WO-2024026076-A2 | SUBSTITUTED 3,4-DIHYDROQUINOLINONE INHIBITORS OF TSHR | SEPTERNA, INC. (US) | 2024-02-01 | — | — | WO | disclosed |