Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | AR | P10275 | 2/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TTR | P02766 | 1/20 | 0.36 |
| ▸ | MYC | P01106 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27195844 | 0.87 | HSD17B10 (0.49) | ALDH1A1HSD17B10KDM4EMAPK1CYP2C19 | |
| SCHEMBL27195818 | 0.86 | AR (0.40) | ALDH1A1ARWDR5LMNAHSD17B10 | |
| Lithium Ion SCHEMBL30806914 | 0.84 | ALDH1A1 (0.51) | ALDH1A1WDR5LMNAHSD17B10KDM4E | |
| SCHEMBL27195872 | 0.84 | KDM4E (0.45) | ALDH1A1WDR5LMNAHSD17B10KDM4E | |
| SCHEMBL26407606 | 0.71 | HTR1A (0.44) | ALDH1A1LMNAMAPK1SMN1; SMN2POLB | |
| SCHEMBL12752917 | 0.69 | HSD17B10 (0.57) | ALDH1A1WDR5LMNAHSD17B10KDM4E | |
| SCHEMBL25675736 | 0.68 | LRRK2 (0.38) | ALDH1A1KDM4ESMN1; SMN2TTRALOX15 | |
| SCHEMBL26418611 | 0.67 | HTR1A (0.49) | ALDH1A1LMNAMAPK1SMN1; SMN2POLB | |
| SCHEMBL27195834 | 0.67 | CYP3A4 (0.40) | ALDH1A1WDR5HSD17B10KDM4EMAPK1 | |
| SCHEMBL26407343 | 0.66 | HTR1A (0.48) | ALDH1A1LMNAMAPK1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4581017-A1 | NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS | Biodol Therapeutics (FR) | 2025-07-09 | — | — | EP | disclosed |
| WO-2024079072-A1 | NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS | BIODOL THERAPEUTICS (FR) | 2024-04-18 | — | — | WO | disclosed |
| EP-4353712-A1 | NEW N-HETEROARYLBENZAMIDES DERIVATIVES AS FLT3 INHIBITORS | Biodol Therapeutics (FR) | 2024-04-17 | — | — | EP | disclosed |