Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.65 |
| ▸ | TP53 | P04637 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.61 |
| ▸ | MEN1 | O00255 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | GFER | P55789 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | THRB | P10828 | 2/20 | 0.54 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7366935 | 0.91 | HDAC1 (0.56) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL5940974 | 0.83 | MAPT (0.47) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| Bromide SCHEMBL27458290 | 0.82 | MAPT (0.46) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| Bromide SCHEMBL2951034 | 0.82 | MAPT (0.46) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL3965014 | 0.80 | MAPT (0.52) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL3965007 | 0.80 | MAPT (0.52) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL30808588 | 0.79 | MAPT (0.52) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL25600122 | 0.78 | TP53 (0.55) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL10588893 | 0.77 | HDAC1 (0.55) | MAPTTP53ALDH1A1KDM4EMEN1 | |
| SCHEMBL4056244 | 0.77 | HDAC1 (0.75) | MAPTTP53ALDH1A1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023250002-A1 | IDENTIFICATION OF NOVEL BENZOTHIAZONES AS TAU-SH3 INTERACTION INHIBITORS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | SOUTHERN RESEARCH INSTITUTE (US) | 2023-12-28 | — | — | WO | disclosed |