Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | JAK1 | P23458 | 2/20 | 0.39 |
| ▸ | ACACB | O00763 | 5/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | NAMPT | P43490 | 2/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1195132 | 0.82 | AVPR1A (0.47) | POLBHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL1195130 | 0.82 | AVPR1A (0.47) | POLBHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL13542676 | 0.81 | MEN1 (0.44) | POLBOPRD1OPRK1ACACBHDAC1 | |
| SCHEMBL2001801 | 0.80 | POLB (0.42) | POLBOPRD1OPRK1JAK2JAK1 | |
| SCHEMBL4264395 | 0.80 | AVPR1A (0.47) | POLBHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL1689606 | 0.80 | AVPR1A (0.47) | POLBHDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL1995317 | 0.79 | NAMPT (0.45) | POLBGPR119NAMPT | |
| SCHEMBL16086668 | 0.78 | USP30 (0.44) | POLBACACBNR1H2HDAC1HDAC8 | |
| SCHEMBL5578656 | 0.78 | TNKS (0.44) | GPR119HDAC1HDAC8HDAC6MEN1 | |
| SCHEMBL5578756 | 0.78 | ALDH1A1 (0.46) | GPR119HDAC1HDAC8HDAC6MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543544-A1 | TYROSINE KINASE 2 INHIBITORS AND USES THEREOF | Biogen MA Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| CN-119866338-A | Tyrosine kinase 2 inhibitors and uses thereof | 渤健马萨诸塞州股份有限公司 | 2025-04-22 | — | — | CN | disclosed |
| WO-2023250064-A1 | TYROSINE KINASE 2 INHIBITORS AND USES THEREOF | BIOGEN MA INC. (US) | 2023-12-28 | — | — | WO | disclosed |