Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 2/20 | 0.35 |
| ▸ | TBK1 | Q9UHD2 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 6/20 | 0.34 |
| ▸ | JAK1 | P23458 | 4/20 | 0.34 |
| ▸ | JAK3 | P52333 | 4/20 | 0.34 |
| ▸ | TYK2 | P29597 | 4/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | ACACA | Q13085 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24576970 | 0.85 | PDGFRA (0.41) | IKBKETBK1JAK2JAK1JAK3 | |
| SCHEMBL30809541 | 0.84 | PDGFRA (0.35) | BLKBTKCHRM1PDGFRAHRH3 | |
| Hydrochloric Acid SCHEMBL29759908 | 0.84 | PDGFRA (0.41) | IKBKETBK1JAK2JAK1JAK3 | |
| Hydrochloric Acid SCHEMBL29759944 | 0.84 | IKBKE (0.36) | IKBKETBK1JAK2JAK1JAK3 | |
| Hydrochloric Acid SCHEMBL27185341 | 0.84 | IKBKE (0.36) | IKBKETBK1JAK2JAK1JAK3 | |
| SCHEMBL30809567 | 0.83 | CSF1R (0.34) | CHRM1PDGFRAHRH3PIK3C3IRAK4 | |
| SCHEMBL30809568 | 0.83 | CSF1R (0.34) | CHRM1PDGFRAHRH3PIK3C3IRAK4 | |
| SCHEMBL29759768 | 0.82 | IKBKE (0.42) | IKBKETBK1JAK2TYK2KCNH2 | |
| SCHEMBL24577098 | 0.82 | IKBKE (0.42) | IKBKETBK1JAK2TYK2KCNH2 | |
| SCHEMBL24578020 | 0.81 | IRAK4 (0.36) | JAK2JAK1JAK3TYK2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |