Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 2/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | KIT | P10721 | 1/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.33 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | BLK | P51451 | 1/20 | 0.32 |
| ▸ | BTK | Q06187 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29759824 | 0.86 | ALDH1A1 (0.43) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24577074 | 0.86 | ALDH1A1 (0.43) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL29759628 | 0.86 | PDGFRA (0.34) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24579039 | 0.86 | PDGFRA (0.34) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL30809567 | 0.85 | CSF1R (0.34) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL30809568 | 0.85 | CSF1R (0.34) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL30809572 | 0.84 | IKBKE (0.35) | PDGFRACHRM1HRH3PIK3C3IRAK4 | |
| SCHEMBL29759890 | 0.84 | IKBKE (0.38) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL30809569 | 0.84 | PDGFRA (0.46) | PDGFRACHRM1HRH3CSF1RKIT | |
| SCHEMBL24577737 | 0.83 | ALDH1A1 (0.38) | PDGFRACHRM1HRH3CSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023247596-A1 | PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2023-12-28 | — | — | WO | disclosed |