SCHEMBL30810366

SCHEMBL30810366

COc1c(CBr)cc(Cl)cc1C(=O)O

nearest known ligand 0.52

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 4/20 0.52
ALDH1A1 P00352 4/20 0.47
HSD17B10 Q99714 3/20 0.47
HPGD P15428 2/20 0.47
MRGPRX4 Q96LA9 2/20 0.44
AKR1C4 P17516 1/20 0.40
AKR1C3 P42330 1/20 0.40
AKR1C2 P52895 1/20 0.40
AKR1C1 Q04828 1/20 0.40
APEX1 P27695 1/20 0.39
ACLY P53396 2/20 0.39
CYP3A4 P08684 1/20 0.39
TPMT P51580 1/20 0.38
GAA P10253 2/20 0.38
LCK P06239 1/20 0.38
FYN P06241 1/20 0.38
TSHR P16473 1/20 0.37
TP53 P04637 1/20 0.37
GPR35 Q9HC97 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19612164 0.87 KDM4E (0.55) KDM4EALDH1A1HSD17B10HPGDMRGPRX4
SCHEMBL19612141 0.86 KDM4E (0.43) KDM4EALDH1A1HSD17B10HPGDACLY
SCHEMBL30810239 0.86 KDM4E (0.43) KDM4EALDH1A1HSD17B10HPGDACLY
SCHEMBL30239427 0.82 KDM4E (0.60) KDM4EALDH1A1HSD17B10HPGDAKR1C4
SCHEMBL19627277 0.81 KDM4E (0.50) KDM4EALDH1A1HSD17B10HPGDMRGPRX4
SCHEMBL19627258 0.79 KDM4E (0.48) KDM4EALDH1A1HSD17B10HPGDMRGPRX4
SCHEMBL19627272 0.79 KDM4E (0.48) KDM4EALDH1A1HSD17B10HPGDMRGPRX4
SCHEMBL30810187 0.78 HSD17B10 (0.69) KDM4EALDH1A1HSD17B10HPGDAKR1C4
SCHEMBL8979332 0.78 ALDH1A1 (0.51) KDM4EALDH1A1HSD17B10HPGDMRGPRX4
SCHEMBL7363190 0.78 HSD17B10 (0.69) KDM4EALDH1A1HSD17B10HPGDAKR1C4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4583870-A2 MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER Mito Biopharma, LLC (US) 2025-07-16 EP disclosed
WO-2024054766-A2 MITOCHONDRIAL UNCOUPLERS FOR TREATMENT OF METABOLIC DISEASES AND CANCER MITO BIOPHARMA, LLC (US) 2024-03-14 WO disclosed