Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 17/20 | 0.62 |
| ▸ | DDB1 | Q16531 | 15/20 | 0.62 |
| ▸ | KHK | P50053 | 2/20 | 0.32 |
| ▸ | MAT2A | P31153 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25586560 | 1.00 | CRBN (0.62) | CRBNDDB1KHKMAT2A | |
| SCHEMBL38657472 | 0.88 | DDB1 (0.67) | CRBNDDB1KHK | |
| Hydrochloric Acid SCHEMBL31554745 | 0.87 | DDB1 (0.66) | CRBNDDB1KHK | |
| SCHEMBL38657940 | 0.86 | DDB1 (0.65) | CRBNDDB1 | |
| SCHEMBL25448885 | 0.86 | CRBN (0.62) | CRBNDDB1KHKMAT2A | |
| SCHEMBL23538519 | 0.85 | CRBN (0.69) | CRBNDDB1KHKMAT2A | |
| SCHEMBL24873284 | 0.85 | DDB1 (0.69) | CRBNDDB1KHKMAT2A | |
| Hydrochloric Acid SCHEMBL31520848 | 0.85 | DDB1 (0.64) | CRBNDDB1 | |
| SCHEMBL30738802 | 0.85 | DDB1 (0.61) | CRBNDDB1KHK | |
| SCHEMBL30822474 | 0.85 | DDB1 (0.61) | CRBNDDB1KHK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025087291-A1 | IRAK4 TARGETED DEGRADATION AGENT COMPOUND, AND USE THEREOF | 江苏先声药业有限公司 | 2025-05-01 | — | — | WO | disclosed |
| EP-4543861-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | Nikang Therapeutics, Inc. (US) | 2025-04-30 | — | — | EP | disclosed |
| CN-119630644-A | Bifunctional compounds containing pyrimidine derivatives for degradation of cyclin-dependent kinase 2 via the ubiquitin proteasome pathway | 霖康疗法公司 | 2025-03-14 | — | — | CN | disclosed |
| CN-119431366-A | IRAK4 degradation agent compound and application thereof | 江苏先声药业有限公司 | 2025-02-14 | — | — | CN | disclosed |
| WO-2023249970-A1 | BIFUNCTIONAL COMPOUNDS CONTAINING PYRIMIDINE DERIVATIVES FOR DEGRADING CYCLIN-DEPENDENT KINASE 2 VIA UBIQUITIN PROTEASOME PATHWAY | NIKANG THERAPEUTICS, INC. (US) | 2023-12-28 | — | — | WO | disclosed |