⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3563278 | 0.83 | — | — | |
| SCHEMBL1980233 | 0.78 | — | — | |
| SCHEMBL14690106 | 0.75 | — | — | |
| SCHEMBL1993799 | 0.75 | HCAR2 (0.32) | — | |
| SCHEMBL9901404 | 0.73 | L3MBTL1 (0.34) | — | |
| SCHEMBL2146962 | 0.73 | — | — | |
| SCHEMBL1427543 | 0.73 | TSHR (0.40) | — | |
| SCHEMBL1763533 | 0.72 | — | — | |
| SCHEMBL424664 | 0.72 | SLC6A3 (0.32) | — | |
| SCHEMBL15994632 | 0.71 | SLC6A3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100227859-A1 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH LLC | 2010-09-09 | — | — | US | disclosed |
| EP-2144893-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | Wyeth a Corporation of the State of Delaware (US) | 2010-01-20 | — | — | EP | disclosed |
| WO-2008137816-A2 | TRICYCLIC COMPOUNDS AS MATRIX METALLOPROTEINASE INHIBITORS | WYETH (US) | 2008-11-13 | — | — | WO | disclosed |