Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30813143 | 0.84 | PREP (0.40) | PRMT5WDR77 | |
| SCHEMBL30813139 | 0.84 | LOX (0.44) | — | |
| SCHEMBL30813179 | 0.83 | MEN1 (0.47) | — | |
| SCHEMBL30813118 | 0.81 | ALDH1A1 (0.45) | — | |
| SCHEMBL30813193 | 0.81 | CYP11B1 (0.38) | CYP11B1 | |
| SCHEMBL30813166 | 0.80 | HCRTR1 (0.39) | — | |
| SCHEMBL30813224 | 0.79 | LMNA (0.45) | — | |
| SCHEMBL30813057 | 0.79 | PREP (0.48) | PRMT5WDR77 | |
| SCHEMBL30813181 | 0.79 | PREP (0.36) | — | |
| SCHEMBL19584486 | 0.78 | PREP (0.53) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3455224-B1 | SUBSTITUTED 5,6,7,8-TETRAHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRIDINE-3(2H)-ONES AND 2,5,6,7-TETRAHYDRO-3H-PYRROLO[2,1-C][1,2,4]TRIAZOL-3-ONES, AND USE THEREOF | BAYER AG (DE) | 2024-03-27 | — | — | EP | disclosed |