Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 5/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.37 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.34 |
| ▸ | SIK1 | P57059 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21177846 | 1.00 | PRKDC (0.38) | PRKDCLMNAGAAPIK3CDPIK3R1 | |
| SCHEMBL21177843 | 1.00 | PRKDC (0.38) | PRKDCLMNAGAAPIK3CDPIK3R1 | |
| SCHEMBL21177841 | 0.95 | LMNA (0.41) | PRKDCLMNAGAAPIK3CDPIK3R1 | |
| SCHEMBL21177861 | 0.95 | LMNA (0.41) | PRKDCLMNAGAAPIK3CDPIK3R1 | |
| SCHEMBL21177844 | 0.95 | LMNA (0.41) | PRKDCLMNAGAAPIK3CDPIK3R1 | |
| SCHEMBL21187288 | 0.95 | LMNA (0.41) | PRKDCLMNAGAAPIK3CDPIK3R1 | |
| SCHEMBL30823286 | 0.95 | LMNA (0.41) | PRKDCLMNAGAAPIK3CDPIK3R1 | |
| SCHEMBL21179454 | 0.89 | ERBB2 (0.38) | PRKDCERBB2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL21179453 | 0.89 | ERBB2 (0.38) | PRKDCERBB2BMPR1BBMPR1ATGFBR1 | |
| SCHEMBL21187304 | 0.87 | ERBB2 (0.35) | PRKDCLMNAGAAPIK3CDPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111757876-B | DNA-PK inhibitors | 沃泰克斯药物股份有限公司 | 2024-03-22 | — | — | CN | disclosed |
| EP-3740480-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2024-03-06 | — | — | EP | disclosed |