Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.35 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | BRD1 | O95696 | 1/20 | 0.33 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.32 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | SRC | P12931 | 1/20 | 0.32 |
| ▸ | AHR | P35869 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822647 | 0.87 | CYP1A2 (0.35) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL30822667 | 0.84 | JAK2 (0.39) | JAK2JAK1TYK2JAK3GRM2 | |
| SCHEMBL30822652 | 0.81 | JAK2 (0.39) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL30822701 | 0.79 | JAK2 (0.37) | JAK2JAK1TYK2JAK3GRM2 | |
| SCHEMBL30822700 | 0.79 | JAK2 (0.37) | JAK2JAK1TYK2JAK3GRM2 | |
| SCHEMBL30822666 | 0.79 | JAK2 (0.37) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL30822711 | 0.78 | CCNA2 (0.39) | JAK2JAK1TYK2JAK3GRIA1 | |
| SCHEMBL30822687 | 0.77 | JAK2 (0.39) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL29164865 | 0.76 | PIK3CD (0.39) | — | |
| SCHEMBL30822694 | 0.73 | JAK2 (0.37) | JAK2JAK1TYK2JAK3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117659001-A | Aminopyrimidine derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-03-08 | — | — | CN | disclosed |