Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.37 |
| ▸ | JAK1 | P23458 | 2/20 | 0.37 |
| ▸ | TYK2 | P29597 | 2/20 | 0.37 |
| ▸ | JAK3 | P52333 | 2/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.30 |
| ▸ | DHODH | Q02127 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822700 | 0.88 | JAK2 (0.37) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822652 | 0.84 | JAK2 (0.39) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822667 | 0.84 | JAK2 (0.39) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822666 | 0.81 | JAK2 (0.37) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822735 | 0.79 | JAK2 (0.37) | JAK2JAK1TYK2JAK3MAPT | |
| SCHEMBL30822711 | 0.78 | CCNA2 (0.39) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL30822687 | 0.75 | JAK2 (0.39) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30822741 | 0.72 | ALK (0.41) | JAK2GAAMAPT | |
| SCHEMBL30822710 | 0.71 | CYP1A2 (0.40) | JAK2JAK1TYK2JAK3GAA | |
| SCHEMBL30541884 | 0.68 | POLB (0.45) | JAK2JAK1TYK2JAK3MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117659001-A | Aminopyrimidine derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-03-08 | — | — | CN | disclosed |