Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822715 | 0.90 | EGFR (0.33) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL30822709 | 0.79 | ALK (0.36) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL30822695 | 0.78 | GRM1 (0.32) | — | |
| SCHEMBL30822687 | 0.76 | JAK2 (0.39) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL30822664 | 0.74 | CYP1A2 (0.37) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL30822732 | 0.73 | PARP1 (0.33) | EGFR | |
| SCHEMBL30822648 | 0.72 | PIK3CD (0.35) | — | |
| SCHEMBL29164788 | 0.72 | PIK3CD (0.35) | — | |
| SCHEMBL30822685 | 0.70 | CHEK1 (0.39) | — | |
| SCHEMBL17336303 | 0.67 | PARP1 (0.42) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117659001-A | Aminopyrimidine derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-03-08 | — | — | CN | disclosed |