Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 2/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.35 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 3/20 | 0.34 |
| ▸ | SYK | P43405 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30822669 | 0.79 | JAK2 (0.34) | JAK2JAK1TYK2JAK3EGFR | |
| SCHEMBL30822667 | 0.78 | JAK2 (0.39) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL30822706 | 0.75 | PIK3CD (0.35) | ALKMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL29164747 | 0.75 | PIK3CD (0.35) | ALKMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL29164749 | 0.75 | PIK3CD (0.35) | ALKMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL30822741 | 0.75 | ALK (0.41) | ALKJAK2KDM4ELMNAHTT | |
| SCHEMBL30822718 | 0.73 | TYMS (0.39) | ALKMEN1KMT2ASMN1; SMN2NPSR1 | |
| SCHEMBL30822720 | 0.71 | ALK (0.49) | ALKJAK2AURKASYKNTRK1 | |
| SCHEMBL30822710 | 0.69 | CYP1A2 (0.40) | ALKJAK2JAK1TYK2JAK3 | |
| SCHEMBL30822708 | 0.69 | AURKA (0.41) | ALKKDM4ENPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117659001-A | Aminopyrimidine derivatives and their use in medicine | 广东东阳光药业股份有限公司 | 2024-03-08 | — | — | CN | disclosed |