Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.57 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | NAMPT | P43490 | 2/20 | 0.53 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 4/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | AKT1 | P31749 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LOX | P28300 | 1/20 | 0.47 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26928711 | 1.00 | HDAC3 (0.57) | HDAC3HDAC1HDAC2HPGDNAMPT | |
| SCHEMBL15610973 | 0.80 | MAPT (0.51) | HPGDBRAFRAF1TP53KMT2A | |
| SCHEMBL29784637 | 0.78 | CYP11B1 (0.65) | HDAC3HDAC1HDAC2NAMPTSMYD3 | |
| SCHEMBL17643849 | 0.78 | SMYD3 (0.57) | HDAC3HDAC1HDAC2SMYD3AKT1 | |
| SCHEMBL1519827 | 0.78 | CYP11B1 (0.65) | HDAC3HDAC1HDAC2NAMPTSMYD3 | |
| SCHEMBL1519811 | 0.78 | SMYD3 (0.60) | HDAC3HDAC1HDAC2NAMPTSMYD3 | |
| SCHEMBL8488280 | 0.78 | NAMPT (0.64) | HPGDNAMPTKMT2AALDH1A1 | |
| SCHEMBL15747587 | 0.77 | ALDH1A1 (0.71) | HDAC3HDAC1HDAC2HPGDBRAF | |
| SCHEMBL28437816 | 0.76 | SMYD3 (0.58) | HDAC3HDAC1HDAC2SMYD3AKT1 | |
| SCHEMBL12600054 | 0.76 | SMYD3 (0.49) | HDAC3HDAC1HDAC2SMYD3KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240101531-A1 | PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | XENON PHARMACEUTICALS INC. (CA) | 2024-03-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240101531-A1 | PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | KCNA1, KCNB1, KCNB2 | HDAC3 952/4885HDAC1 1071/4885HDAC2 1203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.