Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | APEX1 | P27695 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | STAT6 | P42226 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.51 |
| ▸ | HTR2A | P28223 | 1/20 | 0.51 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.51 |
| ▸ | HPGD | P15428 | 4/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21885818 | 0.83 | CYP1A2 (0.52) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL21826862 | 0.76 | CYP1A2 (0.48) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL21826865 | 0.76 | CYP1A2 (0.48) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL774785 | 0.74 | CYP1A2 (0.73) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL29138950 | 0.74 | CYP1A2 (0.73) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL5837665 | 0.73 | CYP1A2 (1.00) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL10759434 | 0.73 | ALDH1A1 (0.74) | MAPK1MAPTPOLBAPEX1RECQL | |
| SCHEMBL7796151 | 0.72 | CYP1A2 (0.65) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL9353698 | 0.72 | MAPT (0.67) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 | |
| SCHEMBL9353714 | 0.72 | PTGS2 (0.65) | CYP1A2CYP2D6CYP3A4CYP2C19L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250099478-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2025-03-27 | — | — | US | disclosed |
| CN-118613483-A | Plasma kallikrein inhibitors | 默沙东有限责任公司 | 2024-09-06 | — | — | CN | disclosed |
| WO-2023146809-A9 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-03-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250099478-A1 | PLASMA KALLIKREIN INHIBITORS | KLKB1, SERPINE1, KLK5 | CYP1A2 2669/4885CYP2D6 3240/4885CYP3A4 2535/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.